Pancreas is a manufacturing unit of insulin and certain essential digestive enzymes in our body. Pancreatic cancer approximately happens in 1 out of 10,000 people. It occurs as malignant neoplasm (cancerous tumor) due to the abnormal cellular growth of various pancreatic cells. Studies have proved that pancreatic cancers can be malignant as there are very good circulations and communications in and around the organ. Alcoholism and viral infections can be the leading factors with the 5th most common cancer related mortal disease worldwide.
Multiple factors superimposed together could lead to this condition as follows:
About 5–10% of pancreatic cancer patients have certainly a familial incidence of similar illness. Gene mutation due to biological, physical, chemical factors in combination could lead to this condition.
As per gender, there are not much concerns. But age group of 60 years old and higher are at higher risk especially if they are known as alcoholism.
Smoking: cigarette smoking is becoming a deadly factor because of close access from mouth to pancreas, thereby dripping of smoke and irritants from mouth.
Poor intake of anti-oxidants, fiber rich diets including vegetables and fruits.
Carcinogenic diets including sugar and amino acids from red meat. Processed meat will definitely be a major risk.
Concentrated carbonate drinks, ether, and benzyl compounds.
Obesity adds 50% to the risk.
Diabetes mellitus and insulin deprivation is an associated factor in this case.
Chronic pancreatitis, peptic ulcers and if you have frequent gastritis can also be risky. Watch for Helicobacter Pylori Infections.
Alcoholism is the most common cause factor because if one is alcoholic on a regular basis, it suppresses the pancreatic activity and circulation. Gradual carcinogenic progression will then damage the pancreatic mucus membrane which turns to become a cancer.
Clinical picture is so vast because a cancer in the pancreas can hinder digestion, metabolism, circulatory and vascular functions leading to verity of symptoms as follows:
A radiating pain in the abdomen which usually radiate towards back.
Heartburn is a condition in which HCL secretion gets amplified and acid stomach is the result leading to burning sensation. It can also be associated with ulceration.
Lack of hunger and frequent nausea and vomiting.
Frequent passage of loose stools.
Unexpected weight loss.
Painless jaundice leading to Bilirubin and Bilirubin variations in the blood with yellowish discoloration on mucous membranes.
Some patients might even go for a brief state of clinical depression.
Pulmonary embolisms and diabetes mellitus may be the possible outcome due to the failure of pancreatic cells to produce insulin.
Treatment of pancreatic primarily depends on the stage of the disease and age. Surgery is the 1st line of management of pancreatic cancer. Chemotherapy then
usually starts immediately after a successful surgery, however pancreatic cancer has a high rate of recurrence especially if it was diagnosed at a later stage of
Surgery: Surgery is the ultimate option in case treatment by drugs fail. Pancreatoduodenectomy is done when cancer is located near duodenum and pancreatic junction. Surgery for tumors in the pancreatic tail and body is also done in case of tail end tumors. Successful surgery and subsequent chemotherapy could prolong patient’s life for a limit of time!
Radiation therapy: Radiation therapy by strong beams of X-rays and protons are used to destroy cancer cells.
Modern science invented Targeted therapy: Where drugs attack specific abnormalities of a tumor cell.